Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Alyssa C Parker; Joseph Van Amburg; J Brett Heimlich; Yash Pershad; Nicole Angelina Mickels; Taralynn Mack; Paul Brent Ferrell Jr; Michael R Savona; Angela Jones; Alexander G Bick

doi:10.1182/blood.2024026555

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Blood. 2024 Nov 20:blood.2024026555. doi: 10.1182/blood.2024026555. Online ahead of print.

Affiliations

¹ Vanderbilt University, Nashville, Tennessee, United States.
² Vanderbilt University Medical Center, Nashville, Tennessee, United States.
³ Vanderbilt University Medical Center, United States.
⁴ Vanderbilt Technologies for Advanced Genomics, United States.

PMID: 39565983
DOI: 10.1182/blood.2024026555

Abstract

We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared to interpretation based on variant allele fraction only.