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Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells.
Pascual-Pasto G, McIntyre B, Giudice AM, Alikarami F, Morrissey A, Matlaga S, Hofmann TJ, Burgueño V, Harvey K, Martinez D, Shah AC, Foster JB, Pogoriler J, Eagle RC, Carcaboso AM, Shields CL, Leahey AM, Bosse KR. Pascual-Pasto G, et al. Clin Cancer Res. 2024 Aug 15;30(16):3578-3591. doi: 10.1158/1078-0432.CCR-24-0221. Clin Cancer Res. 2024. PMID: 38864848
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, Ward A, McSteen B, Labella KM, Keskula P, Tracy A, Connor C, Clinton CM, Church AJ, Crompton BD, Janeway KA, Van Hare B, Sandak D, Gjoerup O, Bandopadhayay P, Clemons PA, Schreiber SL, Root DE, Gokhale PC, Chi SN, Mullen EA, Roberts CW, Kadoch C, Beroukhim R, Ligon KL, Boehm JS, Hahn WC. Hong AL, et al. Elife. 2019 Mar 12;8:e44161. doi: 10.7554/eLife.44161. Elife. 2019. PMID: 30860482 Free PMC article.