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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson WL, Yoneyama Y, Chaturvedi P, Zorn AM, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers RP, Subramanian GM, Hwa V, Takebe T. Kimura M, et al. Cell. 2022 Oct 27;185(22):4216-4232.e16. doi: 10.1016/j.cell.2022.09.031. Epub 2022 Oct 13. Cell. 2022. PMID: 36240780 Free PMC article.
Human liver model systems in a dish.
Thompson WL, Takebe T. Thompson WL, et al. Dev Growth Differ. 2021 Jan;63(1):47-58. doi: 10.1111/dgd.12708. Epub 2021 Feb 2. Dev Growth Differ. 2021. PMID: 33423319 Free PMC article. Review.
Organogenesis in vitro.
Iwasawa K, Takebe T. Iwasawa K, et al. Curr Opin Cell Biol. 2021 Dec;73:84-91. doi: 10.1016/j.ceb.2021.06.007. Epub 2021 Aug 2. Curr Opin Cell Biol. 2021. PMID: 34352726 Free PMC article. Review.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon.
Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM. Múnera JO, et al. Cell Stem Cell. 2023 Nov 2;30(11):1434-1451.e9. doi: 10.1016/j.stem.2023.10.002. Cell Stem Cell. 2023. PMID: 37922878 Free PMC article.
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T. Kawakami E, et al. Cell Stem Cell. 2023 Oct 5;30(10):1315-1330.e10. doi: 10.1016/j.stem.2023.09.001. Cell Stem Cell. 2023. PMID: 37802037 Free PMC article.
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice.
Bouffi C, Wikenheiser-Brokamp KA, Chaturvedi P, Sundaram N, Goddard GR, Wunderlich M, Brown NE, Staab JF, Latanich R, Zachos NC, Holloway EM, Mahe MM, Poling HM, Vales S, Fisher GW, Spence JR, Mulloy JC, Zorn AM, Wells JM, Helmrath MA. Bouffi C, et al. Nat Biotechnol. 2023 Jun;41(6):824-831. doi: 10.1038/s41587-022-01558-x. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702898 Free PMC article.
Narrative engineering of the liver.
Lee IS, Takebe T. Lee IS, et al. Curr Opin Genet Dev. 2022 Aug;75:101925. doi: 10.1016/j.gde.2022.101925. Epub 2022 Jun 11. Curr Opin Genet Dev. 2022. PMID: 35700688 Free PMC article. Review.
46 results