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A global view of the genetic basis of Alzheimer disease.
Reitz C, Pericak-Vance MA, Foroud T, Mayeux R. Reitz C, et al. Nat Rev Neurol. 2023 May;19(5):261-277. doi: 10.1038/s41582-023-00789-z. Epub 2023 Apr 6. Nat Rev Neurol. 2023. PMID: 37024647 Free PMC article. Review.
Genetic associations with dementia-related proteinopathy: Application of item response theory.
Katsumata Y, Fardo DW, Shade LMP, Wu X, Karanth SD, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Gauthreaux K, Mock C, Kukull WA, Abner EL, Nelson PT; Alzheimer's Disease Neuroimaging Initiative; National Alzheimer's Coordinating Center. Katsumata Y, et al. Alzheimers Dement. 2024 Apr;20(4):2906-2921. doi: 10.1002/alz.13741. Epub 2024 Mar 9. Alzheimers Dement. 2024. PMID: 38460116 Free PMC article.
The Role of X Chromosome in Alzheimer's Disease Genetics.
Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL; VA Million Veteran Program; Gaziano JM, Logue M, Napolioni V, Greicius MD. Belloy ME, et al. medRxiv [Preprint]. 2024 Apr 23:2024.04.22.24306094. doi: 10.1101/2024.04.22.24306094. medRxiv. 2024. Update in: JAMA Neurol. 2024 Oct 1;81(10):1032-1042. doi: 10.1001/jamaneurol.2024.2843. PMID: 38712163 Free PMC article. Updated. Preprint.
DNA from multiple viral species is associated with Alzheimer's disease risk.
Tejeda M, Farrell J, Zhu C, Wetzler L, Lunetta KL, Bush WS, Martin ER, Wang LS, Schellenberg GD, Pericak-Vance MA, Haines JL, Farrer LA, Sherva R. Tejeda M, et al. Alzheimers Dement. 2024 Jan;20(1):253-265. doi: 10.1002/alz.13414. Epub 2023 Aug 14. Alzheimers Dement. 2024. PMID: 37578203 Free PMC article.
Replication study of AD-associated rare variants.
Neupane A, Lenny B, Budde JP, Wang F, Norton J, Morris JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga C, Fernández MV. Neupane A, et al. Alzheimers Dement. 2022 Apr;18(4):858-862. doi: 10.1002/alz.12583. Epub 2022 Feb 1. Alzheimers Dement. 2022. PMID: 35103389 Free PMC article. No abstract available.
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.
Chemparathy A, Guen YL, Chen S, Lee EG, Leong L, Gorzynski J, Xu G, Belloy M, Kasireddy N, Tauber AP, Williams K, Stewart I, Wingo T, Lah J, Jayadev S, Hales C, Peskind E, Child DD, Keene CD, Cong L, Ashley E, Yu CE, Greicius MD. Chemparathy A, et al. medRxiv [Preprint]. 2023 Jul 24:2023.07.20.23292771. doi: 10.1101/2023.07.20.23292771. medRxiv. 2023. Update in: Neuron. 2024 Apr 3;112(7):1110-1116.e5. doi: 10.1016/j.neuron.2024.01.008. PMID: 37547016 Free PMC article. Updated. Preprint.
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites.
Tong T, Zhu C, Farrell JJ, Khurshid Z; Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative; Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Tong T, et al. Alzheimers Res Ther. 2024 Oct 23;16(1):234. doi: 10.1186/s13195-024-01601-w. Alzheimers Res Ther. 2024. PMID: 39444005 Free PMC article.
Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry.
Nuytemans K, Rajabli F, Jean-Francois M, Kurup JT, Adams LD, Starks TD, Whitehead PL, Kunkle BW, Caban-Holt A, Haines JL, Cuccaro ML, Vance JM, Byrd GS, Beecham GW, Reitz C, Pericak-Vance MA; NIA-LOAD Family-Based Study; Alzheimer’s Disease Sequencing Project. Nuytemans K, et al. Neurobiol Aging. 2024 Jan;133:125-133. doi: 10.1016/j.neurobiolaging.2023.10.010. Epub 2023 Oct 31. Neurobiol Aging. 2024. PMID: 37952397 Free article.
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