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18 results

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Page 1
Drugging an undruggable pocket on KRAS.
Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB. Kessler D, et al. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332011 Free PMC article.
Drugging the undruggable RAS: Mission possible?
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Cox AD, et al. Nat Rev Drug Discov. 2014 Nov;13(11):828-51. doi: 10.1038/nrd4389. Epub 2014 Oct 17. Nat Rev Drug Discov. 2014. PMID: 25323927 Free PMC article. Review.
Fragment-based drug discovery using NMR spectroscopy.
Harner MJ, Frank AO, Fesik SW. Harner MJ, et al. J Biomol NMR. 2013 Jun;56(2):65-75. doi: 10.1007/s10858-013-9740-z. Epub 2013 May 18. J Biomol NMR. 2013. PMID: 23686385 Free PMC article. Review.
Detection of internal exon deletion with exon Del.
Guo Y, Zhao S, Lehmann BD, Sheng Q, Shaver TM, Stricker TP, Pietenpol JA, Shyr Y. Guo Y, et al. BMC Bioinformatics. 2014 Oct 16;15(1):332. doi: 10.1186/1471-2105-15-332. BMC Bioinformatics. 2014. PMID: 25322818 Free PMC article.
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
Patrone JD, Pelz NF, Bates BS, Souza-Fagundes EM, Vangamudi B, Camper DV, Kuznetsov AG, Browning CF, Feldkamp MD, Frank AO, Gilston BA, Olejniczak ET, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW. Patrone JD, et al. ChemMedChem. 2016 Apr 19;11(8):893-9. doi: 10.1002/cmdc.201500479. Epub 2016 Jan 8. ChemMedChem. 2016. PMID: 26748787 Free PMC article.
18 results