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Page 1
Hyperammonemia and proteostasis in cirrhosis.
Dasarathy S, Hatzoglou M. Dasarathy S, et al. Curr Opin Clin Nutr Metab Care. 2018 Jan;21(1):30-36. doi: 10.1097/MCO.0000000000000426. Curr Opin Clin Nutr Metab Care. 2018. PMID: 29035972 Free PMC article. Review.
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Jobava R, et al. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. Mol Cell. 2021. PMID: 34686314 Free PMC article.
Translational control of breast cancer plasticity.
Jewer M, Lee L, Leibovitch M, Zhang G, Liu J, Findlay SD, Vincent KM, Tandoc K, Dieters-Castator D, Quail DF, Dutta I, Coatham M, Xu Z, Puri A, Guan BJ, Hatzoglou M, Brumwell A, Uniacke J, Patsis C, Koromilas A, Schueler J, Siegers GM, Topisirovic I, Postovit LM. Jewer M, et al. Nat Commun. 2020 May 19;11(1):2498. doi: 10.1038/s41467-020-16352-z. Nat Commun. 2020. PMID: 32427827 Free PMC article.
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Chen CW, et al. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. Nat Commun. 2022. PMID: 35941159 Free PMC article.
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Ghaddar N, Wang S, Woodvine B, Krishnamoorthy J, van Hoef V, Darini C, Kazimierczak U, Ah-Son N, Popper H, Johnson M, Officer L, Teodósio A, Broggini M, Mann KK, Hatzoglou M, Topisirovic I, Larsson O, Le Quesne J, Koromilas AE. Ghaddar N, et al. Nat Commun. 2021 Jul 30;12(1):4651. doi: 10.1038/s41467-021-24661-0. Nat Commun. 2021. PMID: 34330898 Free PMC article.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Krokowski D, et al. Cell Rep. 2022 Jul 19;40(3):111092. doi: 10.1016/j.celrep.2022.111092. Cell Rep. 2022. PMID: 35858571 Free PMC article.
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.
Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A. Kaspar S, et al. Sci Adv. 2021 May 26;7(22):eabf0971. doi: 10.1126/sciadv.abf0971. Print 2021 May. Sci Adv. 2021. PMID: 34039602 Free PMC article.
62 results