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Page 1
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.
Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer RE, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, Mulkearns-Hubert EE, Johnson S, Alvarado J, Rich JN, Holland EC, Paddison PJ, Patel AP, Stauffer SR, Hubert CG, Lathia JD. Mitchell K, et al. Genes Dev. 2023 Feb 1;37(3-4):86-102. doi: 10.1101/gad.349803.122. Epub 2023 Feb 2. Genes Dev. 2023. PMID: 36732025 Free PMC article.
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival.
Wirsching HG, Felsberg J, Prummer M, Moisoiu V, Lourman R, Hertler C, Antonios M, Cimino PJ, Roth P, Gorlia T, Prins RM, Cloughesy T, Wen PY, Holland EC, Reifenberger G, Weller M. Wirsching HG, et al. Acta Neuropathol. 2023 Oct;146(4):647-649. doi: 10.1007/s00401-023-02617-6. Epub 2023 Aug 13. Acta Neuropathol. 2023. PMID: 37573572 Free PMC article. No abstract available.
All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis.
Rao A, Zhang X, Cillo AR, Sussman JH, Sandlesh P, Tarbay AC, Mallela AN, Cardello C, Krueger K, Xu J, Li A, Xu J, Patterson J, Akca E, Angione A, Jaman E, Kim WJ, Allen J, Venketeswaran A, Zinn PO, Parise R, Beumer J, Duensing A, Holland EC, Ferris R, Bagley SJ, Bruno TC, Vignali DAA, Agnihotri S, Amankulor NM. Rao A, et al. bioRxiv [Preprint]. 2024 Apr 13:2024.04.09.588752. doi: 10.1101/2024.04.09.588752. bioRxiv. 2024. PMID: 38645178 Free PMC article. Preprint.
Phase separation of YAP-MAML2 differentially regulates the transcriptome.
Chung CI, Yang J, Yang X, Liu H, Ma Z, Szulzewsky F, Holland EC, Shen Y, Shu X. Chung CI, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2310430121. doi: 10.1073/pnas.2310430121. Epub 2024 Feb 5. Proc Natl Acad Sci U S A. 2024. PMID: 38315854 Free PMC article.
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC. Thirimanne HN, et al. Cell Genom. 2024 Jun 12;4(6):100566. doi: 10.1016/j.xgen.2024.100566. Epub 2024 May 23. Cell Genom. 2024. PMID: 38788713 Free PMC article.
RNA Polymerase II hypertranscription in cancer FFPE samples.
Henikoff S, Henikoff JG, Paranal RM, Greene JE, Zheng Y, Russell ZR, Szulzewsky F, Kugel S, Holland EC, Ahmad K. Henikoff S, et al. bioRxiv [Preprint]. 2024 May 21:2024.02.28.582647. doi: 10.1101/2024.02.28.582647. bioRxiv. 2024. PMID: 38559075 Free PMC article. Preprint.
17 results