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Page 1
Cellular senescence: at the nexus between ageing and diabetes.
Palmer AK, Gustafson B, Kirkland JL, Smith U. Palmer AK, et al. Diabetologia. 2019 Oct;62(10):1835-1841. doi: 10.1007/s00125-019-4934-x. Epub 2019 Aug 27. Diabetologia. 2019. PMID: 31451866 Free PMC article. Review.
Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents.
Dańczak-Pazdrowska A, Gornowicz-Porowska J, Polańska A, Krajka-Kuźniak V, Stawny M, Gostyńska A, Rubiś B, Nourredine S, Ashiqueali S, Schneider A, Tchkonia T, Wyles SP, Kirkland JL, Masternak MM. Dańczak-Pazdrowska A, et al. Aging Cell. 2023 Jun;22(6):e13845. doi: 10.1111/acel.13845. Epub 2023 Apr 11. Aging Cell. 2023. PMID: 37042069 Free PMC article. Review.
Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Prata LGPL, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Espindola-Netto JM, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Camell CD, et al. Science. 2021 Jul 16;373(6552):eabe4832. doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Science. 2021. PMID: 34103349 Free PMC article.
The role of cellular senescence in ageing and endocrine disease.
Khosla S, Farr JN, Tchkonia T, Kirkland JL. Khosla S, et al. Nat Rev Endocrinol. 2020 May;16(5):263-275. doi: 10.1038/s41574-020-0335-y. Epub 2020 Mar 11. Nat Rev Endocrinol. 2020. PMID: 32161396 Free PMC article. Review.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Wang L, et al. Cell Metab. 2022 Jan 4;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22. Cell Metab. 2022. PMID: 34813734 Free PMC article.
Transplanting old organs promotes senescence in young recipients.
Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG. Iske J, et al. Am J Transplant. 2024 Mar;24(3):391-405. doi: 10.1016/j.ajt.2023.10.013. Epub 2023 Oct 31. Am J Transplant. 2024. PMID: 37913871
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.
Chaib S, López-Domínguez JA, Lalinde-Gutiérrez M, Prats N, Marin I, Boix O, García-Garijo A, Meyer K, Muñoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Pérez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. Chaib S, et al. Nat Cancer. 2024 Mar;5(3):448-462. doi: 10.1038/s43018-023-00712-x. Epub 2024 Jan 24. Nat Cancer. 2024. PMID: 38267628 Free PMC article.
Senolytic drugs: from discovery to translation.
Kirkland JL, Tchkonia T. Kirkland JL, et al. J Intern Med. 2020 Nov;288(5):518-536. doi: 10.1111/joim.13141. Epub 2020 Aug 4. J Intern Med. 2020. PMID: 32686219 Free PMC article. Review.
72 results