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Biomarker changes preceding symptom onset in genetic prion disease.
Vallabh SM, Mortberg MA, Allen SW, Kupferschmid AC, Kivisäkk P, Hammerschlag BL, Bolling A, Trombetta BA, Devitte-McKee K, Ford AM, Sather L, Duffy G, Rivera A, Gerber J, McManus AJ, Minikel EV, Arnold SE. Vallabh SM, et al. medRxiv [Preprint]. 2023 Dec 18:2023.12.18.23300042. doi: 10.1101/2023.12.18.23300042. medRxiv. 2023. Update in: Neurology. 2024 Jul 23;103(2):e209506. doi: 10.1212/WNL.0000000000209506 PMID: 38196583 Free PMC article. Updated. Preprint.
Clinical Trials and Tribulations in the COVID-19 Era.
Weinberg MS, Patrick RE, Schwab NA, Owoyemi P, May R, McManus AJ, Gerber J, Harper DG, Arnold SE, Forester B. Weinberg MS, et al. Am J Geriatr Psychiatry. 2020 Sep;28(9):913-920. doi: 10.1016/j.jagp.2020.05.016. Epub 2020 May 19. Am J Geriatr Psychiatry. 2020. PMID: 32507686 Free PMC article.
Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease.
Vallabh SM, Minikel EV, Williams VJ, Carlyle BC, McManus AJ, Wennick CD, Bolling A, Trombetta BA, Urick D, Nobuhara CK, Gerber J, Duddy H, Lachmann I, Stehmann C, Collins SJ, Blennow K, Zetterberg H, Arnold SE. Vallabh SM, et al. BMC Med. 2020 Jun 18;18(1):140. doi: 10.1186/s12916-020-01608-8. BMC Med. 2020. PMID: 32552681 Free PMC article.
Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.
Mortberg MA, Zhao HT, Reidenbach AG, Gentile JE, Kuhn E, O'Moore J, Dooley PM, Connors TR, Mazur C, Allen SW, Trombetta BA, McManus A, Moore MR, Liu J, Cabin DE, Kordasiewicz HB, Mathews J, Arnold SE, Vallabh SM, Minikel EV. Mortberg MA, et al. JCI Insight. 2022 Mar 22;7(6):e156532. doi: 10.1172/jci.insight.156532. JCI Insight. 2022. PMID: 35133987 Free PMC article.
A single-cell map of antisense oligonucleotide activity in the brain.
Mortberg MA, Gentile JE, Nadaf N, Vanderburg C, Simmons S, Dubinsky D, Slamin A, Maldonado S, Petersen CL, Jones N, Kordasiewicz HB, Zhao HT, Vallabh SM, Minikel EV. Mortberg MA, et al. bioRxiv [Preprint]. 2023 Feb 14:2023.02.14.528473. doi: 10.1101/2023.02.14.528473. bioRxiv. 2023. Update in: Nucleic Acids Res. 2023 Aug 11;51(14):7109-7124. doi: 10.1093/nar/gkad371 PMID: 36824749 Free PMC article. Updated. Preprint.
Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry.
Minikel EV, Kuhn E, Cocco AR, Vallabh SM, Hartigan CR, Reidenbach AG, Safar JG, Raymond GJ, McCarthy MD, O'Keefe R, Llorens F, Zerr I, Capellari S, Parchi P, Schreiber SL, Carr SA. Minikel EV, et al. Mol Cell Proteomics. 2019 Dec;18(12):2388-2400. doi: 10.1074/mcp.RA119.001702. Epub 2019 Sep 26. Mol Cell Proteomics. 2019. PMID: 31558565 Free PMC article.
Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development.
Vallabh SM, Nobuhara CK, Llorens F, Zerr I, Parchi P, Capellari S, Kuhn E, Klickstein J, Safar JG, Nery FC, Swoboda KJ, Geschwind MD, Zetterberg H, Arnold SE, Minikel EV, Schreiber SL. Vallabh SM, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7793-7798. doi: 10.1073/pnas.1901947116. Epub 2019 Apr 1. Proc Natl Acad Sci U S A. 2019. PMID: 30936307 Free PMC article.