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2023 4
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Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.
Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME. Gonzales MM, et al. Nat Med. 2023 Oct;29(10):2481-2488. doi: 10.1038/s41591-023-02543-w. Epub 2023 Sep 7. Nat Med. 2023. PMID: 37679434 Free PMC article. Clinical Trial.
Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.
Walker JM, Orr ME, Orr TC, Thorn EL, Christie TD, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond E, White CL 3rd, Crary JF, Farrell K, Kautz TF, Daoud EV, Richardson TE. Walker JM, et al. Alzheimers Dement. 2024 Feb;20(2):783-797. doi: 10.1002/alz.13484. Epub 2023 Sep 30. Alzheimers Dement. 2024. PMID: 37777848 Free PMC article.
Therapeutic targeting of senescent cells in the CNS.
Riessland M, Ximerakis M, Jarjour AA, Zhang B, Orr ME. Riessland M, et al. Nat Rev Drug Discov. 2024 Nov;23(11):817-837. doi: 10.1038/s41573-024-01033-z. Epub 2024 Sep 30. Nat Rev Drug Discov. 2024. PMID: 39349637 Review.
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease.
Gonzales MM, Garbarino VR, Kautz T, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews J, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland J, Salardini A, Seshadri S, Musi N, Orr ME. Gonzales MM, et al. Res Sq [Preprint]. 2023 Apr 24:rs.3.rs-2809973. doi: 10.21203/rs.3.rs-2809973/v1. Res Sq. 2023. Update in: Nat Med. 2023 Oct;29(10):2481-2488. doi: 10.1038/s41591-023-02543-w. PMID: 37162971 Free PMC article. Updated. Preprint.