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Harnessing Ion-Binding Sites for GPCR Pharmacology.
Zarzycka B, Zaidi SA, Roth BL, Katritch V. Zarzycka B, et al. Pharmacol Rev. 2019 Oct;71(4):571-595. doi: 10.1124/pr.119.017863. Pharmacol Rev. 2019. PMID: 31551350 Free PMC article. Review.
Crystal Structure of the Human Cannabinoid Receptor CB1.
Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Cell. 2016 Oct 20;167(3):750-762.e14. doi: 10.1016/j.cell.2016.10.004. Cell. 2016. PMID: 27768894 Free PMC article.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL. Che T, et al. Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4. Cell. 2018. PMID: 29307491 Free PMC article.
Crystal structures of agonist-bound human cannabinoid receptor CB1.
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5. Nature. 2017. PMID: 28678776 Free PMC article.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, Le Rouzic V, Eans SO, Simons CA, Hunkele A, Subrath J, Pan YX, Javitch JA, McLaughlin JP, Roth BL, Pasternak GW, Katritch V, Majumdar S. Uprety R, et al. Elife. 2021 Feb 8;10:e56519. doi: 10.7554/eLife.56519. Elife. 2021. PMID: 33555255 Free PMC article.
Structural basis for bifunctional peptide recognition at human δ-opioid receptor.
Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V. Fenalti G, et al. Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16. Nat Struct Mol Biol. 2015. PMID: 25686086 Free PMC article.
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