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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.
Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. Srikanth S, et al. Nat Immunol. 2019 Feb;20(2):152-162. doi: 10.1038/s41590-018-0287-8. Epub 2019 Jan 14. Nat Immunol. 2019. PMID: 30643259 Free PMC article.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Choi YJ, et al. Nat Immunol. 2019 Mar;20(3):276-287. doi: 10.1038/s41590-018-0303-z. Epub 2019 Jan 28. Nat Immunol. 2019. PMID: 30692621 Free PMC article.
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target.
Wang W, Shin WJ, Zhang B, Choi Y, Yoo JS, Zimmerman MI, Frederick TE, Bowman GR, Gross ML, Leung DW, Jung JU, Amarasinghe GK. Wang W, et al. Cell Rep. 2020 Jan 7;30(1):153-163.e5. doi: 10.1016/j.celrep.2019.12.020. Cell Rep. 2020. PMID: 31914382 Free PMC article.
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Choi UY, Lee JJ, Park A, Zhu W, Lee HR, Choi YJ, Yoo JS, Yu C, Feng P, Gao SJ, Chen S, Eoh H, Jung JU. Choi UY, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8083-8093. doi: 10.1073/pnas.1918607117. Epub 2020 Mar 25. Proc Natl Acad Sci U S A. 2020. PMID: 32213586 Free PMC article.
21 results