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A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
Sofer T, Kurniansyah N, Granot-Hershkovitz E, Goodman MO, Tarraf W, Broce I, Lipton RB, Daviglus M, Lamar M, Wassertheil-Smoller S, Cai J, DeCarli CS, Gonzalez HM, Fornage M. Sofer T, et al. Alzheimers Res Ther. 2023 Aug 30;15(1):146. doi: 10.1186/s13195-023-01298-3. Alzheimers Res Ther. 2023. PMID: 37649099 Free PMC article.
Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations.
Elgart M, Lyons G, Romero-Brufau S, Kurniansyah N, Brody JA, Guo X, Lin HJ, Raffield L, Gao Y, Chen H, de Vries P, Lloyd-Jones DM, Lange LA, Peloso GM, Fornage M, Rotter JI, Rich SS, Morrison AC, Psaty BM, Levy D, Redline S; NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium; Sofer T. Elgart M, et al. Commun Biol. 2022 Aug 22;5(1):856. doi: 10.1038/s42003-022-03812-z. Commun Biol. 2022. PMID: 35995843 Free PMC article.
Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.
Granot-Hershkovitz E, He S, Bressler J, Yu B, Tarraf W, Rebholz CM, Cai J, Chan Q, Garcia TP, Mosley T, Kristal BS, DeCarli C, Fornage M, Chen GC, Qi Q, Kaplan R, González HM, Sofer T. Granot-Hershkovitz E, et al. Alzheimers Dement. 2023 Apr;19(4):1331-1342. doi: 10.1002/alz.12786. Epub 2022 Sep 16. Alzheimers Dement. 2023. PMID: 36111689 Free PMC article.
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos.
Zhang Y, Elgart M, Granot-Hershkovitz E, Wang H, Tarraf W, Ramos AR, Stickel AM, Zeng D, Garcia TP, Testai FD, Wassertheil-Smoller S, Isasi CR, Daviglus ML, Kaplan R, Fornage M, DeCarli C, Redline S, González HM, Sofer T. Zhang Y, et al. EBioMedicine. 2023 Jan;87:104393. doi: 10.1016/j.ebiom.2022.104393. Epub 2022 Dec 6. EBioMedicine. 2023. PMID: 36493726 Free PMC article.
The Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos.
Mahanna-Gabrielli E, Kuwayama S, Tarraf W, Kaur S, DeBuc DC, Cai J, Daviglus ML, Joslin CE, Lee DJ, Mendoza-Santiesteban C, Stickel AM, Zheng D, González HM, Ramos AR. Mahanna-Gabrielli E, et al. J Alzheimers Dis. 2023;92(4):1257-1267. doi: 10.3233/JAD-221073. J Alzheimers Dis. 2023. PMID: 36872780 Free PMC article.
11 results