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Anticancer agents that counteract tumor glycolysis.
Granchi C, Minutolo F. Granchi C, et al. ChemMedChem. 2012 Aug;7(8):1318-50. doi: 10.1002/cmdc.201200176. Epub 2012 Jun 8. ChemMedChem. 2012. PMID: 22684868 Free PMC article. Review.
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M 2nd, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Xie H, et al. Cell Metab. 2014 May 6;19(5):795-809. doi: 10.1016/j.cmet.2014.03.003. Epub 2014 Apr 10. Cell Metab. 2014. PMID: 24726384 Free PMC article.