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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. Leng K, et al. Nat Neurosci. 2022 Nov;25(11):1528-1542. doi: 10.1038/s41593-022-01180-9. Epub 2022 Oct 27. Nat Neurosci. 2022. PMID: 36303069 Free PMC article.
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintarić L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. Dorrier CE, et al. Nat Neurosci. 2021 Feb;24(2):234-244. doi: 10.1038/s41593-020-00770-9. Epub 2021 Feb 1. Nat Neurosci. 2021. PMID: 33526922 Free PMC article.
14 results