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Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Sánchez Pérez P, Ruiz Robles JM, Bermúdez-Jiménez FJ, Díaz-Agustín A, Martínez de Benito F, Arias-Santiago S, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Circ Res. 2024 Apr 12;134(8):e52-e71. doi: 10.1161/CIRCRESAHA.123.323895. Epub 2024 Mar 18. Circ Res. 2024. PMID: 38497220 Free article.
Mechanism of PKCε regulation of cardiac GIRK channel gating.
Gada KD, Chang M, Chandrashekar A, Plant LD, Noujaim SF, Logothetis DE. Gada KD, et al. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2212325120. doi: 10.1073/pnas.2212325120. Epub 2022 Dec 30. Proc Natl Acad Sci U S A. 2023. PMID: 36584301 Free PMC article.
Cryoballoon cardioneuroablation: New electrophysiological insights.
Herweg B, Patel RS, Noujaim S, Spano J, Mencer N, Vijayaraman P. Herweg B, et al. Heart Rhythm O2. 2024 Mar 20;5(4):209-216. doi: 10.1016/j.hroo.2024.03.004. eCollection 2024 Apr. Heart Rhythm O2. 2024. PMID: 38690146 Free PMC article.
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Pérez PS, Robles JMR, Bermúdez-Jiménez FJ, Díaz-Agustín A, de Benito FM, Santiago SA, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. bioRxiv [Preprint]. 2023 Jun 8:2023.06.07.544151. doi: 10.1101/2023.06.07.544151. bioRxiv. 2023. PMID: 37333254 Free PMC article. Preprint.