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Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice.
Gao S, Tang AT, Wang M, Buchholz DW, Imbiakha B, Yang J, Chen X, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, August A, Jurado KA, Morrisey EE, Aguilar-Carreno H, Kahn ML. Gao S, et al. Front Cardiovasc Med. 2023 Sep 26;10:1266276. doi: 10.3389/fcvm.2023.1266276. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37823176 Free PMC article.
Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection.
Tang AT, Buchholz DW, Szigety KM, Imbiakha B, Gao S, Frankfurter M, Wang M, Yang J, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, Monreal IA, Sahler J, August A, Zhu X, Jurado KA, Xu M, Morrisey EE, Millar SE, Aguilar HC, Kahn ML. Tang AT, et al. PLoS Biol. 2023 Feb 6;21(2):e3001989. doi: 10.1371/journal.pbio.3001989. eCollection 2023 Feb. PLoS Biol. 2023. PMID: 36745682 Free PMC article.
Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness.
Hoofnagle MH, Hess A, Nalugo M, Ghosh S, Hughes SW, Fuchs A, Welsh JD, Kahn ML, Bochicchio GV, Randolph GJ, Leonard JM, Turnbull IR. Hoofnagle MH, et al. J Trauma Acute Care Surg. 2023 Aug 1;95(2):197-204. doi: 10.1097/TA.0000000000003945. Epub 2023 Apr 19. J Trauma Acute Care Surg. 2023. PMID: 37072887 Free PMC article.