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Page 1
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J. Miao R, et al. Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3. Immunity. 2023. PMID: 37924812 Free PMC article.
Modulating mitofusins to control mitochondrial function and signaling.
Zacharioudakis E, Agianian B, Kumar Mv V, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Mathew C, Wei P, Tsirigos A, Tait SWG, Kirshenbaum LA, Kitsis RN, Gavathiotis E. Zacharioudakis E, et al. Nat Commun. 2022 Jul 7;13(1):3775. doi: 10.1038/s41467-022-31324-1. Nat Commun. 2022. PMID: 35798717 Free PMC article.
Heart Disease and Cancer: Are the Two Killers Colluding?
Kitsis RN, Riquelme JA, Lavandero S. Kitsis RN, et al. Circulation. 2018 Aug 14;138(7):692-695. doi: 10.1161/CIRCULATIONAHA.118.033907. Circulation. 2018. PMID: 30359137 Free PMC article. No abstract available.
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Chelko SP, et al. Sci Transl Med. 2021 Feb 17;13(581):eabf0891. doi: 10.1126/scitranslmed.abf0891. Sci Transl Med. 2021. PMID: 33597260 Free PMC article.
Small-molecule allosteric inhibitors of BAX.
Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E. Garner TP, et al. Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4. Nat Chem Biol. 2019. PMID: 30718816 Free PMC article.
17 results