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Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.
Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Tschope C, Pieske B, Lebeche D, Schultheiss HP, Hajjar RJ, Poller WC. Suckau L, et al. Circulation. 2009 Mar 10;119(9):1241-52. doi: 10.1161/CIRCULATIONAHA.108.783852. Epub 2009 Feb 23. Circulation. 2009. PMID: 19237664 Free PMC article.
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Peña JR, et al. J Mol Cell Cardiol. 2010 Dec;49(6):993-1002. doi: 10.1016/j.yjmcc.2010.09.010. Epub 2010 Sep 18. J Mol Cell Cardiol. 2010. PMID: 20854827 Free PMC article.