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A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM. Kawasaki H, et al. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83. doi: 10.1073/pnas.95.22.13278. Proc Natl Acad Sci U S A. 1998. PMID: 9789079 Free PMC article.
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R. Pasvolsky R, et al. J Exp Med. 2007 Jul 9;204(7):1571-82. doi: 10.1084/jem.20070058. Epub 2007 Jun 18. J Exp Med. 2007. PMID: 17576779 Free PMC article.
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