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The many lives of Myc in the pancreatic β-cell.
Rosselot C, Baumel-Alterzon S, Li Y, Brill G, Lambertini L, Katz LS, Lu G, Garcia-Ocaña A, Scott DK. Rosselot C, et al. J Biol Chem. 2021 Jan-Jun;296:100122. doi: 10.1074/jbc.REV120.011149. Epub 2020 Dec 2. J Biol Chem. 2021. PMID: 33239359 Free PMC article. Review.
Nrf2: The Master and Captain of Beta Cell Fate.
Baumel-Alterzon S, Katz LS, Brill G, Garcia-Ocaña A, Scott DK. Baumel-Alterzon S, et al. Trends Endocrinol Metab. 2021 Jan;32(1):7-19. doi: 10.1016/j.tem.2020.11.002. Epub 2020 Nov 23. Trends Endocrinol Metab. 2021. PMID: 33243626 Free PMC article. Review.
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation.
Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN. Fu A, et al. Nat Metab. 2020 May;2(5):432-446. doi: 10.1038/s42255-020-0199-4. Epub 2020 May 11. Nat Metab. 2020. PMID: 32694660 Free PMC article.
Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.
Kumar K, Wang P, Wilson J, Zlatanic V, Berrouet C, Khamrui S, Secor C, Swartz EA, Lazarus M, Sanchez R, Stewart AF, Garcia-Ocana A, DeVita RJ. Kumar K, et al. J Med Chem. 2020 Mar 26;63(6):2986-3003. doi: 10.1021/acs.jmedchem.9b01379. Epub 2020 Feb 19. J Med Chem. 2020. PMID: 32003560 Free PMC article.
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Levasseur EM, et al. Sci Signal. 2019 Dec 3;12(610):eaax0715. doi: 10.1126/scisignal.aax0715. Sci Signal. 2019. PMID: 31796630 Free PMC article.