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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. Godoy P, et al. Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Arch Toxicol. 2013. PMID: 23974980 Free PMC article. Review.
Sterile inflammation in acute liver injury: myth or mystery?
Woolbright BL, Jaeschke H. Woolbright BL, et al. Expert Rev Gastroenterol Hepatol. 2015;9(8):1027-9. doi: 10.1586/17474124.2015.1060855. Expert Rev Gastroenterol Hepatol. 2015. PMID: 26186639 Free PMC article. Review.
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Akakpo JY, Ramachandran A, Jaeschke H. Akakpo JY, et al. Expert Opin Drug Metab Toxicol. 2020 Nov;16(11):1039-1050. doi: 10.1080/17425255.2020.1817896. Epub 2020 Sep 14. Expert Opin Drug Metab Toxicol. 2020. PMID: 32862728 Free PMC article. Review.
Therapeutic targets for cholestatic liver injury.
Woolbright BL, Jaeschke H. Woolbright BL, et al. Expert Opin Ther Targets. 2016;20(4):463-75. doi: 10.1517/14728222.2016.1103735. Epub 2015 Oct 19. Expert Opin Ther Targets. 2016. PMID: 26479335 Free PMC article. Review.
111 results