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Page 1
The signalling conformation of the insulin receptor ectodomain.
Weis F, Menting JG, Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P, Langer T, Müller CW, Dreyer MK, Lawrence MC. Weis F, et al. Nat Commun. 2018 Oct 24;9(1):4420. doi: 10.1038/s41467-018-06826-6. Nat Commun. 2018. PMID: 30356040 Free PMC article.
Protective hinge in insulin opens to enable its receptor engagement.
Menting JG, Yang Y, Chan SJ, Phillips NB, Smith BJ, Whittaker J, Wickramasinghe NP, Whittaker LJ, Pandyarajan V, Wan ZL, Yadav SP, Carroll JM, Strokes N, Roberts CT Jr, Ismail-Beigi F, Milewski W, Steiner DF, Chauhan VS, Ward CW, Weiss MA, Lawrence MC. Menting JG, et al. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3395-404. doi: 10.1073/pnas.1412897111. Epub 2014 Aug 4. Proc Natl Acad Sci U S A. 2014. PMID: 25092300 Free PMC article.
31 results