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2022 3
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Page 1
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration.
Khazaei S, Chen CCL, Andrade AF, Kabir N, Azarafshar P, Morcos SM, França JA, Lopes M, Lund PJ, Danieau G, Worme S, Adnani L, Nzirorera N, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ, Bryant L, Hébert S, Tong B, Sihota TS, Faury D, Puligandla E, Jawhar W, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam B, Gomes CC, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K, Cocanougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI, Kleinman CL, Garzia L, Jabado N. Khazaei S, et al. Cell. 2023 Mar 16;186(6):1162-1178.e20. doi: 10.1016/j.cell.2023.02.023. Cell. 2023. PMID: 36931244 Free PMC article.
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Li Y, et al. Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi: 10.1016/j.molcel.2022.09.007. Epub 2022 Oct 6. Mol Cell. 2022. PMID: 36206767 Free PMC article.
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1.
Thomas JF, Valencia-Sánchez MI, Tamburri S, Gloor SL, Rustichelli S, Godínez-López V, De Ioannes P, Lee R, Abini-Agbomson S, Gretarsson K, Burg JM, Hickman AR, Sun L, Gopinath S, Taylor HF, Sun ZW, Ezell RJ, Vaidya A, Meiners MJ, Cheek MA, Rice WJ, Svetlov V, Nudler E, Lu C, Keogh MC, Pasini D, Armache KJ. Thomas JF, et al. Sci Adv. 2023 Aug 9;9(32):eadg9832. doi: 10.1126/sciadv.adg9832. Epub 2023 Aug 9. Sci Adv. 2023. PMID: 37556531 Free PMC article.
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids.
Flashner S, Martin C, Matsuura N, Shimonosono M, Tomita Y, Morimoto M, Okolo O, Yu VX, Parikh AS, Klein-Szanto AJP, Yan K, Gabre JT, Lu C, Momen-Heravi F, Rustgi AK, Nakagawa H. Flashner S, et al. J Vis Exp. 2022 Dec 23;(190):10.3791/64676. doi: 10.3791/64676. J Vis Exp. 2022. PMID: 36622034 Free PMC article.
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Abini-Agbomson S, Gretarsson K, Shih RM, Hsieh L, Lou T, De Ioannes P, Vasilyev N, Lee R, Wang M, Simon M, Armache JP, Nudler E, Narlikar G, Liu S, Lu C, Armache KJ. Abini-Agbomson S, et al. bioRxiv [Preprint]. 2023 Mar 19:2023.03.17.533220. doi: 10.1101/2023.03.17.533220. bioRxiv. 2023. Update in: Mol Cell. 2023 Aug 17;83(16):2872-2883.e7. doi: 10.1016/j.molcel.2023.07.020. PMID: 36993485 Free PMC article. Updated. Preprint.
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.
Thomas JF, Valencia-Sánchez MI, Tamburri S, Gloor SL, Rustichelli S, Godínez-López V, De Ioannes P, Lee R, Abini-Agbomson S, Gretarsson K, Burg JM, Hickman AR, Sun L, Gopinath S, Taylor H, Meiners MJ, Cheek MA, Rice W, Nudler E, Lu C, Keogh MC, Pasini D, Armache KJ. Thomas JF, et al. bioRxiv [Preprint]. 2023 Feb 23:2023.02.23.529554. doi: 10.1101/2023.02.23.529554. bioRxiv. 2023. Update in: Sci Adv. 2023 Aug 9;9(32):eadg9832. doi: 10.1126/sciadv.adg9832. PMID: 36865140 Free PMC article. Updated. Preprint.
Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma.
Dermawan JKT, Nafa K, Mohanty A, Xu Y, Rijo I, Casanova J, Villafania L, Benhamida J, Kelly CM, Tap WD, Boland PJ, Fabbri N, Healey JH, Ladanyi M, Lu C, Hameed M. Dermawan JKT, et al. Cancer Res Commun. 2023 Mar 14;3(3):431-443. doi: 10.1158/2767-9764.CRC-22-0397. eCollection 2023 Mar. Cancer Res Commun. 2023. PMID: 36926116 Free PMC article.
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson KH, Abini-Agbomson S, Gloor SL, Weinberg DN, McCuiston JL, Kumary VUS, Hickman AR, Sahu V, Lee R, Xu X, Lipieta N, Flashner S, Adeleke OA, Popova IK, Taylor HF, Noll K, Windham CL, Maryanski DN, Venters BJ, Nakagawa H, Keogh MC, Armache KJ, Lu C. Gretarsson KH, et al. Sci Adv. 2024 Aug 30;10(35):eadp0975. doi: 10.1126/sciadv.adp0975. Epub 2024 Aug 28. Sci Adv. 2024. PMID: 39196936 Free PMC article.
11 results