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Page 1
A membrane-associated MHC-I inhibitory axis for cancer immune evasion.
Chen X, Lu Q, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, Cammer M, Wang K, Al-Santli W, Ciantra Z, Guo Q, You J, Sengupta D, Boukhris A, Zhang H, Liu C, Cresswell P, Dahia PLM, Pagano M, Aifantis I, Wang J. Chen X, et al. Cell. 2023 Aug 31;186(18):3903-3920.e21. doi: 10.1016/j.cell.2023.07.016. Epub 2023 Aug 8. Cell. 2023. PMID: 37557169 Free PMC article.
Valine tRNA levels and availability regulate complex I assembly in leukaemia.
Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Thandapani P, et al. Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22. Nature. 2022. PMID: 34937946 Free PMC article.
Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I. Glytsou C, et al. Cancer Discov. 2023 Jul 7;13(7):1656-1677. doi: 10.1158/2159-8290.CD-22-0601. Cancer Discov. 2023. PMID: 37088914 Free PMC article.
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.
Yeaton A, Cayanan G, Loghavi S, Dolgalev I, Leddin EM, Loo CE, Torabifard H, Nicolet D, Wang J, Corrigan K, Paraskevopoulou V, Starczynowski DT, Wang E, Abdel-Wahab O, Viny AD, Stone RM, Byrd JC, Guryanova OA, Kohli RM, Cisneros GA, Tsirigos A, Eisfeld AK, Aifantis I, Guillamot M. Yeaton A, et al. Cancer Discov. 2022 Oct 5;12(10):2392-2413. doi: 10.1158/2159-8290.CD-21-1146. Cancer Discov. 2022. PMID: 35924979 Free PMC article.
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion.
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, Tsirigos A, Perna F, Aifantis I, Kadoch C. Battistello E, et al. Mol Cell. 2023 Apr 20;83(8):1216-1236.e12. doi: 10.1016/j.molcel.2023.02.026. Epub 2023 Mar 20. Mol Cell. 2023. PMID: 36944333 Free PMC article.
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia.
Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. Witkowski MT, et al. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. Nat Immunol. 2022. PMID: 36138187 Free PMC article.
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, Lasry A, Redondo LZ, Choi K, Gong Y, Walker CS, Hueneman K, Bolanos LC, Barreyro L, Lee LH, Greis KD, Vasyliev N, Khodadadi-Jamayran A, Nudler E, Lujambio A, Lowe SW, Aifantis I, Starczynowski DT. Muto T, et al. Cell Stem Cell. 2022 Feb 3;29(2):298-314.e9. doi: 10.1016/j.stem.2021.12.007. Epub 2022 Jan 18. Cell Stem Cell. 2022. PMID: 35045331 Free PMC article.