R01 CA260666/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2021	5
2022	1
2023	9
2024	5

1

Advancing targeted protein degradation for cancer therapy.

Dale B, Cheng M, Park KS, Kaniskan HÜ, Xiong Y, Jin J. Dale B, et al. Nat Rev Cancer. 2021 Oct;21(10):638-654. doi: 10.1038/s41568-021-00365-x. Epub 2021 Jun 15. Nat Rev Cancer. 2021. PMID: 34131295 Free PMC article. Review.

2

TF-PROTACs Enable Targeted Degradation of Transcription Factors.

Liu J, Chen H, Kaniskan HÜ, Xie L, Chen X, Jin J, Wei W. Liu J, et al. J Am Chem Soc. 2021 Jun 16;143(23):8902-8910. doi: 10.1021/jacs.1c03852. Epub 2021 Jun 8. J Am Chem Soc. 2021. PMID: 34100597 Free PMC article.

3

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.

Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. Xiong Y, et al. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. J Am Chem Soc. 2022. PMID: 36448571 Free PMC article.

4

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2.

Wang Z, Liu J, Qiu X, Zhang D, Inuzuka H, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. J Am Chem Soc. 2023 Oct 11;145(40):21871-21878. doi: 10.1021/jacs.3c06023. Epub 2023 Sep 29. J Am Chem Soc. 2023. PMID: 37774414 Free PMC article.

5

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.

Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. J Am Chem Soc. 2024 Mar 20;146(11):7584-7593. doi: 10.1021/jacs.3c13646. Epub 2024 Mar 12. J Am Chem Soc. 2024. PMID: 38469801 Free PMC article.

6

Histone Readers and Their Roles in Cancer.

Wen H, Shi X. Wen H, et al. Cancer Treat Res. 2023;190:245-272. doi: 10.1007/978-3-031-45654-1_8. Cancer Treat Res. 2023. PMID: 38113004 Free PMC article.

7

The MYC-MAF-SAGA axis drives oncogenic gene expression in multiple myeloma.

Wang H, Wen H, Shi X. Wang H, et al. Genes Dev. 2024 Sep 19;38(15-16):693-694. doi: 10.1101/gad.352186.124. Genes Dev. 2024. PMID: 39168637 Free PMC article. Review.

8

TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition.

Xu L, Xuan H, He W, Zhang L, Huang M, Li K, Wen H, Xu H, Shi X. Xu L, et al. Nat Commun. 2023 Sep 2;14(1):5362. doi: 10.1038/s41467-023-41245-2. Nat Commun. 2023. PMID: 37660055 Free PMC article.

9

Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation.

Xuan H, Xu L, Li K, Xuan F, Xu T, Wen H, Shi X. Xuan H, et al. J Mol Biol. 2024 Apr 1;436(7):168413. doi: 10.1016/j.jmb.2023.168413. Epub 2023 Dec 20. J Mol Biol. 2024. PMID: 38135180

10

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.

Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Wei J, et al. J Am Chem Soc. 2021 Sep 22;143(37):15073-15083. doi: 10.1021/jacs.1c04841. Epub 2021 Sep 14. J Am Chem Soc. 2021. PMID: 34520194 Free PMC article.

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