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Page 1
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Khan S, et al. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. Nat Med. 2019. PMID: 31792461 Free PMC article.
Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.
Principe DR, Aissa AF, Kumar S, Pham TND, Underwood PW, Nair R, Ke R, Rana B, Trevino JG, Munshi HG, Benevolenskaya EV, Rana A. Principe DR, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2200143119. doi: 10.1073/pnas.2200143119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476525 Free PMC article.
Targeting BCL-XL in fibrolamellar hepatocellular carcinoma.
Shebl B, Ng D, Lalazar G, Rosemore C, Finkelstein TM, Migler RD, Zheng G, Zhang P, Jiang CS, Qureshi A, Vaughan R, Yarchoan M, de Jong YP, Rice CM, Coffino P, Ortiz MV, Zhou D, Simon SM. Shebl B, et al. JCI Insight. 2022 Sep 8;7(17):e161820. doi: 10.1172/jci.insight.161820. JCI Insight. 2022. PMID: 36073545 Free PMC article.
Piperlongumine conjugates induce targeted protein degradation.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D. Pei J, et al. Cell Chem Biol. 2023 Feb 16;30(2):203-213.e17. doi: 10.1016/j.chembiol.2023.01.004. Epub 2023 Feb 6. Cell Chem Biol. 2023. PMID: 36750097 Free PMC article.
Diversity and Inclusion in Pancreatic Cancer Clinical Trials.
Herremans KM, Riner AN, Winn RA, Trevino JG. Herremans KM, et al. Gastroenterology. 2021 Dec;161(6):1741-1746.e3. doi: 10.1053/j.gastro.2021.06.079. Epub 2021 Aug 17. Gastroenterology. 2021. PMID: 34416276 Free PMC article. Review. No abstract available.
46 results