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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh PJ. Spanogiannopoulos P, et al. Nat Microbiol. 2022 Oct;7(10):1605-1620. doi: 10.1038/s41564-022-01226-5. Epub 2022 Sep 22. Nat Microbiol. 2022. PMID: 36138165 Free PMC article.
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA. Li Z, et al. Nat Chem Biol. 2022 Jul;18(7):751-761. doi: 10.1038/s41589-022-01033-3. Epub 2022 May 30. Nat Chem Biol. 2022. PMID: 35637349 Free PMC article.
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A. Lee JV, et al. Nat Commun. 2022 Jun 27;13(1):3671. doi: 10.1038/s41467-022-31238-y. Nat Commun. 2022. PMID: 35760778 Free PMC article.
Oncogene-regulated release of extracellular vesicles.
Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohnz RA, Avsaroglu B, L'Etoile ND, Perera RM, Nomura DK, Goga A. Kilinc S, et al. Dev Cell. 2021 Jul 12;56(13):1989-2006.e6. doi: 10.1016/j.devcel.2021.05.014. Epub 2021 Jun 11. Dev Cell. 2021. PMID: 34118203 Free PMC article.
Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes.
Winkler J, Tan W, Diadhiou CM, McGinnis CS, Abbasi A, Hasnain S, Durney S, Atamaniuc E, Superville D, Awni L, Lee JV, Hinrichs JH, Wagner PS, Singh N, Hein MY, Borja M, Detweiler AM, Liu SY, Nanjaraj A, Sitarama V, Rugo HS, Neff N, Gartner ZJ, Oliveira Pisco A, Goga A, Darmanis S, Werb Z. Winkler J, et al. J Clin Invest. 2024 Sep 3;134(17):e164227. doi: 10.1172/JCI164227. J Clin Invest. 2024. PMID: 39225101 Free PMC article.