R01 CA219187/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2018	1
2019	2
2020	3
2021	2
2023	1
2024	1

1

DNA repair fidelity in stem cell maintenance, health, and disease.

Mani C, Reddy PH, Palle K. Mani C, et al. Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165444. doi: 10.1016/j.bbadis.2019.03.017. Epub 2019 Apr 4. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 30953688 Free PMC article. Review.

2

The multifunctional protein PACS-1 is required for HDAC2- and HDAC3-dependent chromatin maturation and genomic stability.

Mani C, Tripathi K, Luan S, Clark DW, Andrews JF, Vindigni A, Thomas G, Palle K. Mani C, et al. Oncogene. 2020 Mar;39(12):2583-2596. doi: 10.1038/s41388-020-1167-x. Epub 2020 Jan 27. Oncogene. 2020. PMID: 31988453 Free PMC article.

3

Racial differences in RAD51 expression are regulated by miRNA-214-5P and its inhibition synergizes with olaparib in triple-negative breast cancer.

Mani C, Acharya G, Saamarthy K, Ochola D, Mereddy S, Pruitt K, Manne U, Palle K. Mani C, et al. Breast Cancer Res. 2023 Apr 20;25(1):44. doi: 10.1186/s13058-023-01615-6. Breast Cancer Res. 2023. PMID: 37081516 Free PMC article.

4

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.

Mani C, Jonnalagadda S, Lingareddy J, Awasthi S, Gmeiner WH, Palle K. Mani C, et al. Breast Cancer Res. 2019 Sep 6;21(1):104. doi: 10.1186/s13058-019-1192-2. Breast Cancer Res. 2019. PMID: 31492187 Free PMC article.

5

Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.

Mani C, Tripathi K, Chaudhary S, Somasagara RR, Rocconi RP, Crasto C, Reedy M, Athar M, Palle K. Mani C, et al. Neoplasia. 2021 Sep;23(9):1002-1015. doi: 10.1016/j.neo.2021.06.010. Epub 2021 Aug 8. Neoplasia. 2021. PMID: 34380074 Free PMC article.

6

Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties.

Gmeiner WH, Dominijanni A, Haber AO, Ghiraldeli LP, Caudell DL, D'Agostino R Jr, Pasche BC, Smith TL, Deng Z, Kiren S, Mani C, Palle K, Brody JR. Gmeiner WH, et al. Mol Cancer Ther. 2021 Mar;20(3):553-563. doi: 10.1158/1535-7163.MCT-20-0516. Epub 2020 Dec 23. Mol Cancer Ther. 2021. PMID: 33361273 Free PMC article.

7

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer.

Acharya G, Mani C, Sah N, Saamarthy K, Young R, Reedy MB, Sobol RW, Palle K. Acharya G, et al. Cell Death Discov. 2024 Jun 11;10(1):278. doi: 10.1038/s41420-024-02040-0. Cell Death Discov. 2024. PMID: 38862485 Free PMC article.

8

Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.

Mani C, Pai S, Papke CM, Palle K, Gmeiner WH. Mani C, et al. Neoplasia. 2018 Dec;20(12):1236-1245. doi: 10.1016/j.neo.2018.10.006. Epub 2018 Nov 12. Neoplasia. 2018. PMID: 30439567 Free PMC article.

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