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Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma.
Moser R, Gurley KE, Nikolova O, Qin G, Joshi R, Mendez E, Shmulevich I, Ashley A, Grandori C, Kemp CJ. Moser R, et al. Oncogene. 2022 Jun;41(24):3355-3369. doi: 10.1038/s41388-022-02330-w. Epub 2022 May 10. Oncogene. 2022. PMID: 35538224
FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition.
Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao M, Fitzgibbon M, Loeb KR, Rodriguez CP, Méndez E, Galloway DA, Sidorova JM, Clurman BE. Diab A, et al. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28287-28296. doi: 10.1073/pnas.2013921117. Epub 2020 Oct 22. Proc Natl Acad Sci U S A. 2020. PMID: 33093209 Free PMC article.
Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer.
Xu C, Nikolova O, Basom RS, Mitchell RM, Shaw R, Moser RD, Park H, Gurley KE, Kao MC, Green CL, Schaub FX, Diaz RL, Swan HA, Jang IS, Guinney J, Gadi VK, Margolin AA, Grandori C, Kemp CJ, Méndez E. Xu C, et al. Clin Cancer Res. 2018 Jun 15;24(12):2828-2843. doi: 10.1158/1078-0432.CCR-17-1339. Epub 2018 Mar 29. Clin Cancer Res. 2018. PMID: 29599409 Free PMC article.
A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.
Méndez E, Rodriguez CP, Kao MC, Raju S, Diab A, Harbison RA, Konnick EQ, Mugundu GM, Santana-Davila R, Martins R, Futran ND, Chow LQM. Méndez E, et al. Clin Cancer Res. 2018 Jun 15;24(12):2740-2748. doi: 10.1158/1078-0432.CCR-17-3796. Epub 2018 Mar 13. Clin Cancer Res. 2018. PMID: 29535125 Free PMC article. Clinical Trial.