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Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Jul;631(8022):857-866. doi: 10.1038/s41586-024-07627-2. Epub 2024 Jul 10. Nature. 2024. PMID: 38987586
TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo.
Kim J, Bose D, Araínga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger F, Martinelli E. Kim J, et al. Nat Commun. 2024 Feb 14;15(1):1348. doi: 10.1038/s41467-024-45555-x. Nat Commun. 2024. PMID: 38355731 Free PMC article.
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.
Cisneros WJ, Walter M, Soliman SHA, Simons LM, Cornish D, Halle AW, Kim EY, Wolinsky SM, Shilatifard A, Hultquist JF. Cisneros WJ, et al. bioRxiv [Preprint]. 2024 Mar 1:2024.03.01.582881. doi: 10.1101/2024.03.01.582881. bioRxiv. 2024. Update in: PLoS Pathog. 2024 Sep 11;20(9):e1012083. doi: 10.1371/journal.ppat.1012083 PMID: 38464055 Free PMC article. Updated. Preprint.
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.
Cisneros WJ, Soliman SHA, Walter M, Simons LM, Cornish D, De Fabritiis S, Halle AW, Kim EY, Wolinsky SM, Lorenzo-Redondo R, Shilatifard A, Hultquist JF. Cisneros WJ, et al. PLoS Pathog. 2024 Sep 11;20(9):e1012083. doi: 10.1371/journal.ppat.1012083. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39259751 Free PMC article.
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism.
Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. Yi B, et al. iScience. 2024 Feb 5;27(3):109107. doi: 10.1016/j.isci.2024.109107. eCollection 2024 Mar 15. iScience. 2024. PMID: 38384847 Free PMC article.