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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.
Bedard M, van der Niet S, Bernard EM, Babunovic G, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB. Bedard M, et al. J Clin Invest. 2023 Mar 15;133(6):e161944. doi: 10.1172/JCI161944. J Clin Invest. 2023. PMID: 36757797 Free PMC article.
Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides.
Mayfield JA, Raman S, Ramnarine AK, Mishra VK, Huang AD, Dudoit S, Buter J, Cheng TY, Young DC, Nair YM, Ouellet IG, Griebel BT, Ma S, Sherman DR, Mallet L, Rhee KY, Minnaard AJ, Branch Moody D. Mayfield JA, et al. PLoS Biol. 2024 Sep 30;22(9):e3002813. doi: 10.1371/journal.pbio.3002813. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39348416 Free PMC article.