R01 AI124491/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2014	1
2015	1
2016	5
2017	3
2018	6
2019	7
2020	5
2021	10
2022	3
2023	5
2024	5

1

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.

Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Sharif H, et al. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189953 Free PMC article.

2

Cryo-EM structures of the active NLRP3 inflammasome disc.

Xiao L, Magupalli VG, Wu H. Xiao L, et al. Nature. 2023 Jan;613(7944):595-600. doi: 10.1038/s41586-022-05570-8. Epub 2022 Nov 28. Nature. 2023. PMID: 36442502 Free PMC article.

3

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.

Andreeva L, David L, Rawson S, Shen C, Pasricha T, Pelegrin P, Wu H. Andreeva L, et al. Cell. 2021 Dec 22;184(26):6299-6312.e22. doi: 10.1016/j.cell.2021.11.011. Epub 2021 Dec 2. Cell. 2021. PMID: 34861190 Free PMC article.

4

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.

Fu J, Wu H. Fu J, et al. Annu Rev Immunol. 2023 Apr 26;41:301-316. doi: 10.1146/annurev-immunol-081022-021207. Epub 2023 Feb 7. Annu Rev Immunol. 2023. PMID: 36750315 Free PMC article. Review.

5

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions.

Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. Münzer P, et al. Front Immunol. 2021 May 28;12:683803. doi: 10.3389/fimmu.2021.683803. eCollection 2021. Front Immunol. 2021. PMID: 34122445 Free PMC article.

6

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Orning P, et al. Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25. Science. 2018. PMID: 30361383 Free PMC article.

7

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Evavold CL, et al. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. Immunity. 2018. PMID: 29195811 Free PMC article.

8

Inflammasome activation at the crux of severe COVID-19.

Vora SM, Lieberman J, Wu H. Vora SM, et al. Nat Rev Immunol. 2021 Nov;21(11):694-703. doi: 10.1038/s41577-021-00588-x. Epub 2021 Aug 9. Nat Rev Immunol. 2021. PMID: 34373622 Free PMC article. Review.

9

Structural transitions enable interleukin-18 maturation and signaling.

Dong Y, Bonin JP, Devant P, Liang Z, Sever AIM, Mintseris J, Aramini JM, Du G, Gygi SP, Kagan JC, Kay LE, Wu H. Dong Y, et al. Immunity. 2024 Jul 9;57(7):1533-1548.e10. doi: 10.1016/j.immuni.2024.04.015. Epub 2024 May 10. Immunity. 2024. PMID: 38733997

10

Structures and functions of the inflammasome engine.

Wang L, Sharif H, Vora SM, Zheng Y, Wu H. Wang L, et al. J Allergy Clin Immunol. 2021 Jun;147(6):2021-2029. doi: 10.1016/j.jaci.2021.04.018. J Allergy Clin Immunol. 2021. PMID: 34092352 Free PMC article. Review.

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