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Page 1
Basement membrane stiffness determines metastases formation.
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR, Clausen-Schaumann H, Erler JT. Reuten R, et al. Nat Mater. 2021 Jun;20(6):892-903. doi: 10.1038/s41563-020-00894-0. Epub 2021 Jan 25. Nat Mater. 2021. PMID: 33495631 Free article.
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases.
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming LK, Vilain C, Abramowicz M, Allan SM, Wang T, Cader MZ, Horsburgh K, Van Agtmael T, Sinha S, Markus HS, Granata A. Al-Thani M, et al. Stem Cell Reports. 2023 Dec 12;18(12):2386-2399. doi: 10.1016/j.stemcr.2023.10.014. Epub 2023 Nov 16. Stem Cell Reports. 2023. PMID: 37977146 Free PMC article.
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.
Pokhilko A, Brezzo G, Handunnetthi L, Heilig R, Lennon R, Smith C, Allan SM, Granata A, Sinha S, Wang T, Markus HS, Naba A, Fischer R, Van Agtmael T, Horsburgh K, Cader MZ. Pokhilko A, et al. J Cereb Blood Flow Metab. 2021 Sep;41(9):2423-2438. doi: 10.1177/0271678X211004307. Epub 2021 Mar 17. J Cereb Blood Flow Metab. 2021. PMID: 33730931 Free PMC article.
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Horsburgh K, et al. Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Clin Sci (Lond). 2018. PMID: 29712883 Free PMC article.
Identification of an Altered Matrix Signature in Kidney Aging and Disease.
Randles MJ, Lausecker F, Kong Q, Suleiman H, Reid G, Kolatsi-Joannou M, Davenport B, Tian P, Falcone S, Potter P, Van Agtmael T, Norman JT, Long DA, Humphries MJ, Miner JH, Lennon R. Randles MJ, et al. J Am Soc Nephrol. 2021 Jul;32(7):1713-1732. doi: 10.1681/ASN.2020101442. Epub 2021 May 28. J Am Soc Nephrol. 2021. PMID: 34049963 Free PMC article.