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Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, Wang Z, Yuan F, Fox M, Zhang HG, Guo H, Tieri D, Kong M, Watson CT, Mitchell RA, Zhang X, McMasters KM, Huang J, Yan J. Morrissey SM, et al. Cell Metab. 2021 Oct 5;33(10):2040-2058.e10. doi: 10.1016/j.cmet.2021.09.002. Epub 2021 Sep 23. Cell Metab. 2021. PMID: 34559989 Free PMC article.
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis.
Ding C, Shrestha R, Zhu X, Geller AE, Wu S, Woeste MR, Li W, Wang H, Yuan F, Xu R, Chariker JH, Hu X, Li H, Tieri D, Zhang HG, Rouchka EC, Mitchell R, Siskind LJ, Zhang X, Xu XG, McMasters KM, Yu Y, Yan J. Ding C, et al. Nat Immunol. 2023 Feb;24(2):239-254. doi: 10.1038/s41590-022-01388-8. Epub 2023 Jan 5. Nat Immunol. 2023. PMID: 36604547 Free PMC article.
Lactate supports a metabolic-epigenetic link in macrophage polarization.
Noe JT, Rendon BE, Geller AE, Conroy LR, Morrissey SM, Young LEA, Bruntz RC, Kim EJ, Wise-Mitchell A, Barbosa de Souza Rizzo M, Relich ER, Baby BV, Johnson LA, Affronti HC, McMasters KM, Clem BF, Gentry MS, Yan J, Wellen KE, Sun RC, Mitchell RA. Noe JT, et al. Sci Adv. 2021 Nov 12;7(46):eabi8602. doi: 10.1126/sciadv.abi8602. Epub 2021 Nov 12. Sci Adv. 2021. PMID: 34767443 Free PMC article.
Exosome-based cancer vaccine for prevention of lung cancer.
Meng S, Whitt AG, Stamp BF, Eaton JW, Li C, Yaddanapudi K. Meng S, et al. Stem Cell Investig. 2023 Jan 9;10:2. doi: 10.21037/sci-2022-030. eCollection 2023. Stem Cell Investig. 2023. PMID: 36742283 Free PMC article.
35 results