DDT exposure, work in agriculture, and time to pregnancy among farmworkers in California

J Occup Environ Med. 2008 Dec;50(12):1335-42. doi: 10.1097/JOM.0b013e31818f684d.

Abstract

Objective: This study examined whether exposure to pesticides, including dichlorodiphenyltrichloroethane (DDT), was associated with longer time to pregnancy (TTP).

Methods: Pregnant women (N = 402) living in a migrant farmworker community were asked how many months they took to conceive. Women reported their and their partners' occupational and home pesticide exposure preceding conception. In a subset (N = 289), levels of DDT and dichlorodiphenyldichloroethylene (DDE), were measured in maternal serum.

Results: No associations were seen with p, p'-DDT, o, p'-DDT, or p, p'-DDE. Maternal occupational pesticide exposure (fecundability odds ratios [fOR] = 0.8, 95% CI: 0.6 to 1.0), home pesticide use (fOR = 0.6, 95% CI: 0.4 to 0.9), and residence within 200 ft of an agricultural field (fOR = 0.7, 95% CI: 0.5 to 1.0) were associated with reduced fecundability (ie, longer TTP).

Conclusions: Longer TTP was seen among women, but not men, reporting exposure to agricultural and home pesticides.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Agriculture*
  • California
  • DDT / adverse effects*
  • DDT / blood
  • Dichlorodiphenyl Dichloroethylene / adverse effects*
  • Dichlorodiphenyl Dichloroethylene / blood
  • Female
  • Fertility*
  • Hispanic or Latino
  • Humans
  • Interviews as Topic
  • Longitudinal Studies
  • Male
  • Mass Spectrometry
  • Maternal Exposure / adverse effects
  • Occupational Exposure / adverse effects*
  • Occupational Exposure / analysis
  • Paternal Exposure / adverse effects
  • Pesticides / adverse effects*
  • Pesticides / blood
  • Pregnancy
  • Proportional Hazards Models
  • Time Factors
  • Transients and Migrants
  • Young Adult

Substances

  • Pesticides
  • Dichlorodiphenyl Dichloroethylene
  • DDT