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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. Bai P, et al. Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004. Cell Metab. 2011. PMID: 21459330 Free PMC article.
Analysis of the human endogenous coregulator complexome.
Malovannaya A, Lanz RB, Jung SY, Bulynko Y, Le NT, Chan DW, Ding C, Shi Y, Yucer N, Krenciute G, Kim BJ, Li C, Chen R, Li W, Wang Y, O'Malley BW, Qin J. Malovannaya A, et al. Cell. 2011 May 27;145(5):787-99. doi: 10.1016/j.cell.2011.05.006. Cell. 2011. PMID: 21620140 Free PMC article.
The coactivator SRC-1 is an essential coordinator of hepatic glucose production.
Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. Louet JF, et al. Cell Metab. 2010 Dec 1;12(6):606-18. doi: 10.1016/j.cmet.2010.11.009. Cell Metab. 2010. PMID: 21109193 Free PMC article.