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Age-associated remodeling of T cell immunity and metabolism.
Han S, Georgiev P, Ringel AE, Sharpe AH, Haigis MC. Han S, et al. Cell Metab. 2023 Jan 3;35(1):36-55. doi: 10.1016/j.cmet.2022.11.005. Epub 2022 Dec 5. Cell Metab. 2023. PMID: 36473467 Free PMC article. Review.
Immune checkpoint receptors in autoimmunity.
Burke KP, Patterson DG, Liang D, Sharpe AH. Burke KP, et al. Curr Opin Immunol. 2023 Feb;80:102283. doi: 10.1016/j.coi.2023.102283. Epub 2023 Jan 28. Curr Opin Immunol. 2023. PMID: 36709596 Free PMC article. Review.
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC. Notarangelo G, et al. Science. 2022 Sep 30;377(6614):1519-1529. doi: 10.1126/science.abj5104. Epub 2022 Sep 29. Science. 2022. PMID: 36173860 Free PMC article.
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.
Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Gonzalez Castro LN, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A, Suvà ML, Wucherpfennig KW. Mathewson ND, et al. Cell. 2021 Mar 4;184(5):1281-1298.e26. doi: 10.1016/j.cell.2021.01.022. Epub 2021 Feb 15. Cell. 2021. PMID: 33592174 Free PMC article.
Emerging concepts in PD-1 checkpoint biology.
Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Pauken KE, et al. Semin Immunol. 2021 Feb;52:101480. doi: 10.1016/j.smim.2021.101480. Epub 2021 May 15. Semin Immunol. 2021. PMID: 34006473 Free PMC article. Review.
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program.
Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R. Hashimoto M, et al. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. Nature. 2022. PMID: 36171288 Free PMC article.
Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy.
Escobar G, Tooley K, Oliveras JP, Huang L, Cheng H, Bookstaver ML, Edwards C, Froimchuk E, Xue C, Mangani D, Krishnan RK, Hazel N, Rutigliani C, Jewell CM, Biasco L, Anderson AC. Escobar G, et al. Cancer Cell. 2023 Sep 11;41(9):1662-1679.e7. doi: 10.1016/j.ccell.2023.08.001. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625402 Free PMC article.
45 results