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Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27.
J Neurochem. 2009.
PMID: 19457132
Free PMC article.
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.
Serneels L, et al.
Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.
Science. 2009.
PMID: 19299585
Free PMC article.
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Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.
Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O.
Herl L, et al.
Mol Cell Neurosci. 2009 Jun;41(2):166-74. doi: 10.1016/j.mcn.2009.02.008. Epub 2009 Mar 9.
Mol Cell Neurosci. 2009.
PMID: 19281847
Free PMC article.
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