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Prevalence and Clinical Implications of a β-Amyloid-Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer Disease.
Erickson P, Simrén J, Brum WS, Ennis GE, Kollmorgen G, Suridjan I, Langhough R, Jonaitis EM, Van Hulle CA, Betthauser TJ, Carlsson CM, Asthana S, Ashton NJ, Johnson SC, Shaw LM, Blennow K, Andreasson U, Bendlin BB, Zetterberg H; ADNI Cohort. Erickson P, et al. JAMA Neurol. 2023 Jul 31;80(9):969-79. doi: 10.1001/jamaneurol.2023.2338. Online ahead of print. JAMA Neurol. 2023. PMID: 37523162 Free PMC article.
A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.
Yang Z, Nasrallah IM, Shou H, Wen J, Doshi J, Habes M, Erus G, Abdulkadir A, Resnick SM, Albert MS, Maruff P, Fripp J, Morris JC, Wolk DA, Davatzikos C; iSTAGING Consortium; Baltimore Longitudinal Study of Aging (BLSA); Alzheimer’s Disease Neuroimaging Initiative (ADNI). Yang Z, et al. Nat Commun. 2021 Dec 3;12(1):7065. doi: 10.1038/s41467-021-26703-z. Nat Commun. 2021. PMID: 34862382 Free PMC article.
Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease.
Pichet Binette A, Franzmeier N, Spotorno N, Ewers M, Brendel M, Biel D; Alzheimer’s Disease Neuroimaging Initiative; Strandberg O, Janelidze S, Palmqvist S, Mattsson-Carlgren N, Smith R, Stomrud E, Ossenkoppele R, Hansson O. Pichet Binette A, et al. Nat Commun. 2022 Nov 4;13(1):6635. doi: 10.1038/s41467-022-34129-4. Nat Commun. 2022. PMID: 36333294 Free PMC article.
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN) Study Group; Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group. Gonneaud J, et al. Nat Commun. 2021 Sep 9;12(1):5346. doi: 10.1038/s41467-021-25492-9. Nat Commun. 2021. PMID: 34504080 Free PMC article.
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.
Milicic L, Vacher M, Porter T, Doré V, Burnham SC, Bourgeat P, Shishegar R, Doecke J, Armstrong NJ, Tankard R, Maruff P, Masters CL, Rowe CC, Villemagne VL, Laws SM; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Australian Imaging Biomarkers and Lifestyle (AIBL) Study. Milicic L, et al. Geroscience. 2022 Jun;44(3):1807-1823. doi: 10.1007/s11357-022-00558-8. Epub 2022 Apr 21. Geroscience. 2022. PMID: 35445885 Free PMC article.