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Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.
Krishnegowda G, Sharma AK, Krzeminski J, Gowda AS, Lin JM, Desai D, Spratt TE, Amin S. Krishnegowda G, et al. Chem Res Toxicol. 2011 Jun 20;24(6):960-7. doi: 10.1021/tx200127j. Epub 2011 May 5. Chem Res Toxicol. 2011. PMID: 21524094 Free PMC article.
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Tang Y, Liu Z, Ding S, Lin CH, Cai Y, Rodriguez FA, Sayer JM, Jerina DM, Amin S, Broyde S, Geacintov NE. Tang Y, et al. Biochemistry. 2012 Dec 4;51(48):9751-62. doi: 10.1021/bi3013577. Epub 2012 Nov 15. Biochemistry. 2012. PMID: 23121427 Free PMC article.