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2018 2
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Page 1
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis.
Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. Reich M, et al. J Hepatol. 2021 Sep;75(3):634-646. doi: 10.1016/j.jhep.2021.03.029. Epub 2021 Apr 17. J Hepatol. 2021. PMID: 33872692 Free article.
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M. Aloia L, et al. Nat Cell Biol. 2019 Nov;21(11):1321-1333. doi: 10.1038/s41556-019-0402-6. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685987 Free PMC article.
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ. Bird TG, et al. Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230. Sci Transl Med. 2018. PMID: 30111642 Free PMC article.
TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.
Dwyer BJ, Jarman EJ, Gogoi-Tiwari J, Ferreira-Gonzalez S, Boulter L, Guest RV, Kendall TJ, Kurian D, Kilpatrick AM, Robson AJ, O'Duibhir E, Man TY, Campana L, Starkey Lewis PJ, Wigmore SJ, Olynyk JK, Ramm GA, Tirnitz-Parker JEE, Forbes SJ. Dwyer BJ, et al. J Hepatol. 2021 Apr;74(4):860-872. doi: 10.1016/j.jhep.2020.11.018. Epub 2020 Nov 19. J Hepatol. 2021. PMID: 33221352 Free article.
Cellular Senescence in Liver Disease and Regeneration.
Ferreira-Gonzalez S, Rodrigo-Torres D, Gadd VL, Forbes SJ. Ferreira-Gonzalez S, et al. Semin Liver Dis. 2021 Jan;41(1):50-66. doi: 10.1055/s-0040-1722262. Epub 2021 Feb 9. Semin Liver Dis. 2021. PMID: 33764485 Free article. Review.
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Chan BKY, Elmasry M, Forootan SS, Russomanno G, Bunday TM, Zhang F, Brillant N, Starkey Lewis PJ, Aird R, Ricci E, Andrews TD, Sison-Young RL, Schofield AL, Fang Y, Lister A, Sharkey JW, Poptani H, Kitteringham NR, Forbes SJ, Malik HZ, Fenwick SW, Park BK, Goldring CE, Copple IM. Chan BKY, et al. Hepatology. 2021 Aug;74(2):973-986. doi: 10.1002/hep.31859. Epub 2021 Jul 13. Hepatology. 2021. PMID: 33872408
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
17 results