MR/M023605/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2017	4
2018	3
2019	8
2020	3
2021	1
2022	2
2024	1

1

Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.

Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Li Z, et al. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. Nature. 2019. PMID: 31666698

2

Mitochondrial integrity in neurodegeneration.

Cowan K, Anichtchik O, Luo S. Cowan K, et al. CNS Neurosci Ther. 2019 Jul;25(7):825-836. doi: 10.1111/cns.13105. Epub 2019 Feb 11. CNS Neurosci Ther. 2019. PMID: 30746905 Free PMC article. Review.

3

Conformation Polymorphism of Polyglutamine Proteins.

Feng X, Luo S, Lu B. Feng X, et al. Trends Biochem Sci. 2018 Jun;43(6):424-435. doi: 10.1016/j.tibs.2018.03.002. Epub 2018 Apr 7. Trends Biochem Sci. 2018. PMID: 29636213 Review.

4

Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease.

Valionyte E, Yang Y, Roberts SL, Kelly J, Lu B, Luo S. Valionyte E, et al. J Mol Biol. 2020 Apr 3;432(8):2673-2691. doi: 10.1016/j.jmb.2019.11.012. Epub 2019 Nov 29. J Mol Biol. 2020. PMID: 31786267 Review.

5

Accumulation of autophagosomes confers cytotoxicity.

Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. Button RW, et al. J Biol Chem. 2017 Aug 18;292(33):13599-13614. doi: 10.1074/jbc.M117.782276. Epub 2017 Jul 3. J Biol Chem. 2017. PMID: 28673965 Free PMC article.

6

Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation.

Yang Y, Valionyte E, Kelly J, Luo S. Yang Y, et al. Autophagy. 2020 Jan;16(1):171-172. doi: 10.1080/15548627.2019.1677323. Epub 2019 Oct 17. Autophagy. 2020. PMID: 31607206 Free PMC article. Review.

7

Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis.

Lu J, Pan Y, Feng X, Lu B. Lu J, et al. Autophagy. 2024 Feb;20(2):451-453. doi: 10.1080/15548627.2023.2274208. Epub 2024 Jan 25. Autophagy. 2024. PMID: 37876230 Free PMC article.

8

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes.

Song H, Li H, Guo S, Pan Y, Fu Y, Zhou Z, Li Z, Wen X, Sun X, He B, Gu H, Zhao Q, Wang C, An P, Luo S, Hu Y, Xie X, Lu B. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798. doi: 10.1093/brain/awy081. Brain. 2018. PMID: 29608652 Free PMC article.

9

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.

Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, Hu B, Zhang J, Lu B, Luo S. Yang Y, et al. Nat Commun. 2019 Aug 21;10(1):3759. doi: 10.1038/s41467-019-11671-2. Nat Commun. 2019. PMID: 31434890 Free PMC article.

10

The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.

Liu X, Li Y, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W, Yang C. Liu X, et al. J Cell Biol. 2017 May 1;216(5):1301-1320. doi: 10.1083/jcb.201608039. Epub 2017 Apr 12. J Cell Biol. 2017. PMID: 28404643 Free PMC article.

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