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Translating cancer 'omics' to improved outcomes.
Vucic EA, Thu KL, Robison K, Rybaczyk LA, Chari R, Alvarez CE, Lam WL. Vucic EA, et al. Genome Res. 2012 Feb;22(2):188-95. doi: 10.1101/gr.124354.111. Genome Res. 2012. PMID: 22301133 Free PMC article.
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Rushlow DE, Mol BM, Kennett JY, Yee S, Pajovic S, Thériault BL, Prigoda-Lee NL, Spencer C, Dimaras H, Corson TW, Pang R, Massey C, Godbout R, Jiang Z, Zacksenhaus E, Paton K, Moll AC, Houdayer C, Raizis A, Halliday W, Lam WL, Boutros PC, Lohmann D, Dorsman JC, Gallie BL. Rushlow DE, et al. Lancet Oncol. 2013 Apr;14(4):327-34. doi: 10.1016/S1470-2045(13)70045-7. Epub 2013 Mar 13. Lancet Oncol. 2013. PMID: 23498719 Free article.
DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.
Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL. Vucic EA, et al. Am J Respir Cell Mol Biol. 2014 May;50(5):912-22. doi: 10.1165/rcmb.2013-0304OC. Am J Respir Cell Mol Biol. 2014. PMID: 24298892 Free PMC article.
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL. Lockwood WW, et al. PLoS One. 2012;7(5):e37775. doi: 10.1371/journal.pone.0037775. Epub 2012 May 21. PLoS One. 2012. PMID: 22629454 Free PMC article.