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Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment.
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Thomson Z, et al. Nat Immunol. 2023 Nov;24(11):1947-1959. doi: 10.1038/s41590-023-01641-8. Epub 2023 Oct 16. Nat Immunol. 2023. PMID: 37845489 Free PMC article.
Understanding T cell aging to improve anti-viral immunity.
Zhang H, Weyand CM, Goronzy JJ, Gustafson CE. Zhang H, et al. Curr Opin Virol. 2021 Dec;51:127-133. doi: 10.1016/j.coviro.2021.09.017. Epub 2021 Oct 21. Curr Opin Virol. 2021. PMID: 34688983 Free PMC article. Review.
Naïve T Cell Quiescence in Immune Aging.
Gustafson CE. Gustafson CE. Adv Geriatr Med Res. 2021;3(3):e210015. doi: 10.20900/agmr20210015. Epub 2021 Jun 26. Adv Geriatr Med Res. 2021. PMID: 34308428 Free PMC article.
Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults.
Gong Q, Sharma M, Kuan EL, Glass MC, Chander A, Singh M, Graybuck LT, Thomson ZJ, LaFrance CM, Zaim SR, Peng T, Okada LY, Genge PC, Henderson KE, Dornisch EM, Layton ED, Wittig PJ, Heubeck AT, Mukuka NM, Reading J, Roll CR, Hernandez V, Parthasarathy V, Stuckey TJ, Musgrove B, Swanson E, Lord C, Weiss MDA, Phalen CG, Mettey RR, Lee KJ, Johanneson JB, Kawelo EK, Garber J, Krishnan U, Smithmyer M, Wherry EJ, Vella L, Henrickson SE, Kopp MS, Savage AK, Becker LA, Meijer P, Coffey EM, Goronzy JJ, Speake C, Bumol TF, Goldrath AW, Torgerson TR, Li XJ, Skene PJ, Buckner JH, Gustafson CE. Gong Q, et al. bioRxiv [Preprint]. 2024 Sep 14:2024.09.10.612119. doi: 10.1101/2024.09.10.612119. bioRxiv. 2024. PMID: 39314416 Free PMC article. Preprint.