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Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing.
Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, Hao D, Wang R, Dai E, Dejima H, Zhang J, Bogatenkova E, Sanchez-Espiridion B, Chang K, Little DR, Bazzi S, Tran LM, Krysan K, Behrens C, Duose DY, Parra ER, Raso MG, Solis LM, Fukuoka J, Zhang J, Sepesi B, Cascone T, Byers LA, Gibbons DL, Chen J, Moghaddam SJ, Ostrin EJ, Rosen D, Heymach JV, Scheet P, Dubinett SM, Fujimoto J, Wistuba II, Stevenson CS, Spira A, Wang L, Kadara H. Sinjab A, et al. Cancer Discov. 2021 Oct;11(10):2506-2523. doi: 10.1158/2159-8290.CD-20-1285. Epub 2021 May 10. Cancer Discov. 2021. PMID: 33972311 Free PMC article.
Lung Cancer and Immunity Markers.
Lim RJ, Liu B, Krysan K, Dubinett SM. Lim RJ, et al. Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2423-2430. doi: 10.1158/1055-9965.EPI-20-0716. Epub 2020 Aug 20. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32856614 Free PMC article. Review.
The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.
Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle DR, Spira AE, Elashoff DA, Wallace WD, Fishbein MC, Dubinett SM. Krysan K, et al. Cancer Res. 2019 Oct 1;79(19):5022-5033. doi: 10.1158/0008-5472.CAN-19-0153. Epub 2019 May 29. Cancer Res. 2019. PMID: 31142513 Free PMC article.
Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer.
Li R, Salehi-Rad R, Crosson W, Momcilovic M, Lim RJ, Ong SL, Huang ZL, Zhang T, Abascal J, Dumitras C, Jing Z, Park SJ, Krysan K, Shackelford DB, Tran LM, Liu B, Dubinett SM. Li R, et al. Cancer Res. 2021 Jun 15;81(12):3295-3308. doi: 10.1158/0008-5472.CAN-20-3564. Epub 2021 Apr 14. Cancer Res. 2021. PMID: 33853830 Free PMC article.
Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells.
Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM. Walser TC, et al. Cancer Res. 2018 Apr 15;78(8):1986-1999. doi: 10.1158/0008-5472.CAN-17-0315. Epub 2018 Feb 5. Cancer Res. 2018. PMID: 29431637 Free PMC article.
Phase I Trial of Intratumoral Injection of CCL21 Gene-Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration.
Lee JM, Lee MH, Garon E, Goldman JW, Salehi-Rad R, Baratelli FE, Schaue D, Wang G, Rosen F, Yanagawa J, Walser TC, Lin Y, Park SJ, Adams S, Marincola FM, Tumeh PC, Abtin F, Suh R, Reckamp KL, Lee G, Wallace WD, Lee S, Zeng G, Elashoff DA, Sharma S, Dubinett SM. Lee JM, et al. Clin Cancer Res. 2017 Aug 15;23(16):4556-4568. doi: 10.1158/1078-0432.CCR-16-2821. Epub 2017 May 3. Clin Cancer Res. 2017. PMID: 28468947 Free PMC article. Clinical Trial.