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Page 1
A microfluidic platform integrating functional vascularized organoids-on-chip.
Quintard C, Tubbs E, Jonsson G, Jiao J, Wang J, Werschler N, Laporte C, Pitaval A, Bah TS, Pomeranz G, Bissardon C, Kaal J, Leopoldi A, Long DA, Blandin P, Achard JL, Battail C, Hagelkruys A, Navarro F, Fouillet Y, Penninger JM, Gidrol X. Quintard C, et al. Among authors: hagelkruys a. Nat Commun. 2024 Feb 16;15(1):1452. doi: 10.1038/s41467-024-45710-4. Nat Commun. 2024. PMID: 38365780 Free PMC article.
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells.
Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N. Garreta E, et al. Among authors: hagelkruys a. Cell Metab. 2022 Jun 7;34(6):857-873.e9. doi: 10.1016/j.cmet.2022.04.009. Epub 2022 May 12. Cell Metab. 2022. PMID: 35561674 Free PMC article.
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Cikes D, Elsayad K, Sezgin E, Koitai E, Torma F, Orthofer M, Yarwood R, Heinz LX, Sedlyarov V, Miranda ND, Taylor A, Grapentine S, Al-Murshedi F, Abot A, Weidinger A, Kutchukian C, Sanchez C, Cronin SJF, Novatchkova M, Kavirayani A, Schuetz T, Haubner B, Haas L, Hagelkruys A, Jackowski S, Kozlov AV, Jacquemond V, Knauf C, Superti-Furga G, Rullman E, Gustafsson T, McDermot J, Lowe M, Radak Z, Chamberlain JS, Bakovic M, Banka S, Penninger JM. Cikes D, et al. Among authors: hagelkruys a. Nat Metab. 2023 Mar;5(3):495-515. doi: 10.1038/s42255-023-00766-2. Epub 2023 Mar 20. Nat Metab. 2023. PMID: 36941451
TSPAN6 is a suppressor of Ras-driven cancer.
Humbert PO, Pryjda TZ, Pranjic B, Farrell A, Fujikura K, de Matos Simoes R, Karim R, Kozieradzki I, Cronin SJF, Neely GG, Meyer TF, Hagelkruys A, Richardson HE, Penninger JM. Humbert PO, et al. Among authors: hagelkruys a. Oncogene. 2022 Apr;41(14):2095-2105. doi: 10.1038/s41388-022-02223-y. Epub 2022 Feb 19. Oncogene. 2022. PMID: 35184157 Free PMC article.
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM. Monteil V, et al. Among authors: hagelkruys a. Cell. 2020 May 14;181(4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. Epub 2020 Apr 24. Cell. 2020. PMID: 32333836 Free PMC article.
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors.
Taubenschmid-Stowers J, Orthofer M, Laemmerer A, Krauditsch C, Rózsová M, Studer C, Lötsch D, Gojo J, Gabler L, Dyczynski M, Efferth T, Hagelkruys A, Widhalm G, Peyrl A, Spiegl-Kreinecker S, Hoepfner D, Bian S, Berger W, Knoblich JA, Elling U, Horn M, Penninger JM. Taubenschmid-Stowers J, et al. Among authors: hagelkruys a. EMBO Mol Med. 2023 Mar 8;15(3):e16959. doi: 10.15252/emmm.202216959. Epub 2023 Feb 6. EMBO Mol Med. 2023. PMID: 36740985 Free PMC article.
Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections.
Monteil V, Kwon H, John L, Salata C, Jonsson G, Vorrink SU, Appelberg S, Youhanna S, Dyczynski M, Leopoldi A, Leeb N, Volz J, Hagelkruys A, Kellner MJ, Devignot S, Michlits G, Foong-Sobis M, Weber F, Lauschke VM, Horn M, Feldmann H, Elling U, Penninger JM, Mirazimi A. Monteil V, et al. Among authors: hagelkruys a. Nat Commun. 2023 Oct 25;14(1):6785. doi: 10.1038/s41467-023-42526-6. Nat Commun. 2023. PMID: 37880247 Free PMC article.
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism.
Cikes D, Leutner M, Cronin SJF, Novatchkova M, Pfleger L, Klepochová R, Lair B, Lac M, Bergoglio C, Viguerie N, Dürnberger G, Roitinger E, Grivej M, Rullman E, Gustafsson T, Hagelkruys A, Tavernier G, Bourlier V, Knauf C, Krebs M, Kautzky-Willer A, Moro C, Krssak M, Orthofer M, Penninger JM. Cikes D, et al. Among authors: hagelkruys a. Nat Aging. 2024 Jan;4(1):80-94. doi: 10.1038/s43587-023-00551-6. Epub 2024 Jan 18. Nat Aging. 2024. PMID: 38238601
Identification of ALK in Thinness.
Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin SJF, Tietge UJF, Müller S, Pospisilik JA, Nagy V, Hui CC, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer FW, Harkany T, Haubensak W, Neely GG, Metspalu A, Hager J, Gheldof N, Penninger JM. Orthofer M, et al. Among authors: hagelkruys a. Cell. 2020 Jun 11;181(6):1246-1262.e22. doi: 10.1016/j.cell.2020.04.034. Epub 2020 May 21. Cell. 2020. PMID: 32442405 Free article.
Correction: TSPAN6 is a suppressor of Ras-driven cancer.
Humbert PO, Pryjda TZ, Pranjic B, Farrell A, Fujikura K, de Matos Simoes R, Karim R, Kozieradzki I, Cronin SJF, Neely GG, Meyer TF, Hagelkruys A, Richardson HE, Penninger JM. Humbert PO, et al. Among authors: hagelkruys a. Oncogene. 2022 Apr;41(14):2138. doi: 10.1038/s41388-022-02265-2. Oncogene. 2022. PMID: 35292775 Free PMC article. No abstract available.
39 results