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Systems pharmacology augments drug safety surveillance.
Clin Pharmacol Ther. 2015 Feb;97(2):151-8. doi: 10.1002/cpt.2. Epub 2014 Dec 20.
Clin Pharmacol Ther. 2015.
PMID: 25670520
Free PMC article.
Large-scale prediction and testing of drug activity on side-effect targets.
Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L.
Lounkine E, et al.
Nature. 2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159.
Nature. 2012.
PMID: 22722194
Free PMC article.
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In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.
Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K.
Lemieux GA, et al.
PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712. Epub 2013 Nov 19.
PLoS Biol. 2013.
PMID: 24260022
Free PMC article.
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