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Blocking VWF platelet binding to treat TTP.
Salles II, Crawley JT. Salles II, et al. Blood. 2012 Oct 25;120(17):3390-2. doi: 10.1182/blood-2012-08-448530. Blood. 2012. PMID: 23100301 Free article.
Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.
Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K. Burdorf L, et al. Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Xenotransplantation. 2016. PMID: 27188532 Free PMC article.