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Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesař V, Cervenka L. Honetschlägerová Z, et al. J Hypertens. 2011 Aug;29(8):1590-601. doi: 10.1097/HJH.0b013e328349062f. J Hypertens. 2011. PMID: 21720266 Free PMC article.
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Certíková Chábová V, et al. Clin Sci (Lond). 2010 Feb 23;118(10):617-32. doi: 10.1042/CS20090459. Clin Sci (Lond). 2010. PMID: 20050826 Free PMC article.
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Neckář J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L. Neckář J, et al. Clin Sci (Lond). 2012 Jun;122(11):513-25. doi: 10.1042/CS20110622. Clin Sci (Lond). 2012. PMID: 22324471 Free PMC article.